metabolic endotoxemia
= the
lipopolysaccharides (aka LPS or else Endotoxins) found in the bacteria cell wall, that (gut) bacteria generate, fall in blood stream (due leaky gut).
sdLDL = doing the atherosclerosis. sdLDL easily oxidized. Going into
endothelium of blood vessels and made the atherosclerosis.
the lipopolysaccharides bind to LDL and make it
sdLDL (here is possible your LDL count to be OK, but sdLDL not)
sdLDL associated with
fatty liver which associated with
gut problems.
Stress increasing the
lipopolysaccharides to your bloodstream ( description above^ ) even when you dont have gut problems, for moment/hours can make it leaky gut. Here is how @ the brain communicates via
vagal nerve with the gut and orders to release
cortisol hormone and this releases also peptides from
mastcells then the gut lining destroyed (inflammation & permeability).
Eating junk food also helps
lipopolysaccharides penetrate the gut.
Bad bacteria
lipopolysaccharides penetrate the gut.
70% of immune system is in the gut, T cells and B cells exist there, LPS when passing to bloodstream stimulate those cells and resulting to produce inflammatory cytokines molecules (inflammation), cause immune problem as well.
Inflammatory cytokines molecules travel to the brain, passing the BBB and causes
inflammation in the brain (mental fog / depression). Depression associated with atherosclerosis.
LSP goes to the
liver and cause
fatty liver and the
muscles made
insulin resistant. You get a
metabolic syndrome,
- blood sugar goes up
- triglycerides go up
- HDL goes down
All those markers are of
atherosclerosis. The
metabolic syndrome causes
inflammatory fat, the LPS going into the
healthy fat tissues, activates again the immune system, that's why we found inflammatory cells in the fat (obesity person : almost the 50% of the fat are inflammatory molecules).
source
ref - 2024 -
Metabolic Endotoxemia - From the Gut to Neurodegeneration
sdLDL to be a better predictor of cardiovascular (CV) risk than
LDL-C, even in patients with low cholesterol
(LDL-C < 100mg/dL).
Similarly, the
JUPITER trial linked
sdLDL to CV deaths . . . even in patients with very low
LDL-C.
source
GPT :
LDL-C (Low-Density Lipoprotein Cholesterol) : Refers to the total cholesterol content within all LDL particles in the bloodstream. It is a common measure used in lipid panels to assess cardiovascular risk. Includes
all sizes of LDL particles, both large and small, and is typically measured in milligrams per deciliter (mg/dL).
sdLDL (Small Dense LDL) : Refers to a
subclass of LDL particles that are
smaller and denser than typical LDL particles. These particles are often considered more
atherogenic (more likely to promote the formation of fatty plaques in arteries) than larger, less dense LDL particles. Elevated levels of
sdLDL are associated with a higher risk of cardiovascular events,
even when total LDL-C levels are within normal ranges.