Just Get More Fiber!

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https://today.duke.edu/2022/07/it-doesn’t-matter-much-which-fiber-you-choose-–-just-get-more-fiber (ref)

There is a link between the health of your gut microbiome and hormones. When gut health isn’t optimal, hormones become imbalanced. A research showing that the microbiome plays a big role in estrogen regulation. ++ Gut Health and Hormones (mirror)

the links and notes here referring fermentable fiber as prebiotic nothing to do with digestive enzymes ( aka amylase, lipase, protease, lactase, bromelain, papain )

The diet of a modern person contains an average of 30gr of fiber / day. To get the daily fiber requirement, you need to eat about 2.5 kg of tomatoes or 1 kg of carrots or 1.25 kg of apples or 2.7 kg of rye bread. calculate your daily fiber requirement



In fact, 80-85% of our immune system is housed in the gut.

This means that one of the main causes of autoimmune diseases ( including eczema ) is the poor functioning of the intestinal tract.

A healthy gastrointestinal system serves as a barrier. It prevents undigested food particles, microbes, toxins and other unwanted substances from entering in the body through the blood.

When the epithelial cells of the intestinal wall are destroyed, the substances are able to make a leak into the body. An attack by the immune system follows and leads to inflammation. source




Probiotics are the good bacteria that should be present in a healthy intestinal tract.
Prebiotics are the specific beneficial sugars that they need to live. They are what Probiotics feed on in order to stay alive. There is no bacteria in any Prebiotic at all.

…and if you don’t have any Prebiotics within your gut, the Probiotics quickly die off, and will no longer exist within one’s gut… the bad bacteria will quickly grow out of control, without these good bacteria being present, causing problems with one’s intestinal health, with one’s digestion, with one’s weight, with one’s emotions, and with one’s physical health overall.

So, the essential thing to understand is that one (Probiotics) are the good bacteria that you should have in your system but which may be lacking, while the other (Prebiotics) are simply the particular types of beneficial sugars that the (Probiotics) bacteria feeds and and require to remain healthy and to stay alive.

You need both of these, the Probiotics (to ensure your intestinal flora (referred to as one’s 'microbiome') is populated with the good bacteria that it needs to be healthy), and you need the Prebiotics, as well, which they feed on, and which allow the good bacteria to thrive, grow, and properly colonize, and ensure they do not quickly die off.... source (mirror)



Because humans can’t digest fiber, it ends up reaching the large intestine mostly unchanged.

This is where fermentable fiber comes into play. These are fibers that the friendly gut bacteria are able to digest (ferment) and use as fuel.

The fiber that benefits your gut bacteria is known as prebiotic fiber, or fermentable fiber. It is considered very beneficial for health and body weight. src

Fermentable fibers
These are the fibers that are broken down by the intestinal bacteria, this process is called fermentation. These fibers are the prebiotics: food for the intestinal bacteria (probiotics).

Non-fermentable fiber
These fibers are not broken down by the intestinal bacteria and leave the body unchanged. However, this does not mean that these fibers have no function! These fibers increase the volume of the intestinal contents and this improves bowel movements. source



Psyllium

Is a form of fermentable fiber (prebiotic) made from the husks of the Plantago ovata (aka psyllium, plantain, ispaghula, metamucil etc) plant seeds, is known as a bulk laxative.

Has the ability to swell up to 50 times its initial volume when added to liquid. The fiber swells strongly and creates a soft gel that supports the composition of the intestinal microflora, thereby improving the passage of food through the digestive tract and at the same time optimizing its function. source

It is plant based natural fiber. Fiber is more than just a regulator, it’s also vital to deliver essential nutrients to the entire body. We obtain fiber most abundantly in our diets from whole grains, fruits and vegetables.

Slippery elm (by ulmus rubra bark) contains a type of soluble fiber called mucilage. It can help regulate blood sugar levels, lower cholesterol, and contribute to a feeling of fullness, among other potential health benefits. (NOW GR wholesale)

Fiber found in 800mg psyllium husk :
Fiber TypeApproximate Percentage
Mucilage10-30%
HemicelluloseVaries, typically 5-15%
CelluloseVaries, typically 5-15%
LigninVaries, typically 1-5%


Fiber found in 800mg slippery elm:
Fiber TypeApproximate Percentage
Mucilage10-20%
CelluloseVaries, typically 10-20%
HemicelluloseVaries, typically 5-15%
LigninVaries, typically 1-5%

there are some differences in the properties and composition of mucilage between the two ( psyllium husk vs slippery elm ).

The mucilage in slippery elm tends to be more gelatinous and viscous compared to that in psyllium husk. This difference in texture may affect how each mucilage interacts with water and the digestive tract. Slippery elm mucilage has traditionally been used to soothe and protect the mucous membranes of the gastrointestinal tract, making it beneficial for conditions such as heartburn, gastritis, and ulcers. Psyllium husk mucilage, on the other hand, is primarily used as a dietary fiber supplement to promote regular bowel movements and relieve constipation.

WARNING - Worsening of autoimmune symptoms (tested & happening)
mucilaginous fiber - the good, the bad, and the gooey (mirror)



other fermentable fiber supplements (prebiotic) :
  • inulin - is a type of soluble fiber found in many plants.
  • dextrin - contains traces of gluten, is made from cornstarch that is roasted and then hydrolyzed by amylase.
  • galactooligosaccharides - found in dairy products, beans, and certain root vegetables.
  • partially hydrolyzed guar gum - FDA-approved dietary fiber that comes from the guar bean plant.
  • Fructooligosaccharides (FOS) - occurs naturally in some plants, including asparagus, onion, leeks, bananas, garlic and Jerusalem artichoke and suppress toxic bacteria.
natural probiotics :
  • Kombucha Is a fermented tea drink with added fruits or vegs for flavor, commonly consumed for its purported health benefits. Known in China as the "elixir of immortality". (ref) -- don't even try, upset stomach. Warning on ready solutions, grow your own.
  • Kimchi is a traditional Korean side dish of salted and fermented vegetables (ref) (refrigerator)
  • Sauerkraut is finely cut raw cabbage that has been fermented by various lactic acid bacteria. (ref)


Vegetable/FruitType of Prebiotic FiberApproximate Percentage per 100g
AsparagusInulin, Fructooligosaccharides (FOS)2-3%
BananasFructooligosaccharides (FOS), Inulin0.5-1%
GarlicInulin, Fructooligosaccharides (FOS)9-16%
OnionsInulin, Fructooligosaccharides (FOS)2-6%
LeeksInulin, Fructooligosaccharides (FOS)3-10%
Chicory RootInulin15-20%
Jerusalem ArtichokesInulin16-20%
Dandelion GreensInulin3-10%
Yacon RootFructooligosaccharides (FOS), Inulin20% (mostly FOS)
JicamaInulin, Oligofructose3-4%
ApplesPectin, Oligosaccharides1-1.5% (Pectin)
Berries (e.g., strawberries, raspberries)Pectin, Polyphenols0.5-1% (Pectin)
TomatoesPectin0.3-0.5%
CarrotsPectin1-2%
Whole Grains (e.g., oats, barley)Beta-glucan, Arabinoxylan3-5% (Beta-glucan in oats)
FlaxseedsMucilage6-8%
SeaweedAlginate, Fucoidan, MucilageVaries widely (up to 20%)
SoybeansGalactooligosaccharides (GOS)1-2%
LentilsGalactooligosaccharides (GOS), Resistant starch1-4% (GOS and RS)
ChickpeasGalactooligosaccharides (GOS), Resistant starch1-4% (GOS and RS)
Green PeasGalactooligosaccharides (GOS)1-2%
LettuceLactucaxanthin, Fiber (including soluble fibers)~1% (total fiber)
CabbageGlucosinolates, Fiber (including soluble fibers)1-3% (total fiber)
PeachesPectin, Soluble Fiber1-2% (Pectin and Soluble Fiber)
PlumsSorbitol, Pectin1-2% (Pectin)
ApricotsPectin, Mucilage, Soluble Fiber1-2% (Pectin and Mucilage)
PearsPectin, Fructooligosaccharides (FOS)3-4% (Pectin and FOS)
OkraMucilage2-3%
Psyllium HuskMucilage20-30%
Aloe VeraMucilageVaries widely
Chia SeedsMucilage5-10%

Asparagus is rich in fiber, but it goes one step further (tested&working) in promoting gut health. In a nonhuman clinical trial, eating cooked asparagus appeared to reduce colon inflammation in instances of colitis (inflammation of the colon). Researchers identified a flavonoid called rutin as contributing to this effect. source

Rutin, a flavonoid known for its antioxidant properties, is found in a variety of foods beyond asparagus. Here are some common dietary sources of rutin:

Food ItemApproximate Rutin Content (mg/100g)
Buckwheat (aka φαγόπυρο) [1] [2]450-500 mg
Capers (aka κάπαρη)300-500 mg
Chamomile100-500 mg
Apples (with skin)10-40 mg
Asparagus30-50 mg
Citrus Fruits (rind)10-20 mg
Berries (Mulberries)5-15 mg
Green Tea30-50 mg
Black Tea20-40 mg
Figs20-30 mg
Olives10-20 mg
Spinach10-20 mg



The gut microflora and intestinal epithelial cells: a continuing dialogue
The Health Benefits of Psyllium Husk
Ορισμός και Διάκριση Φυτικών Ινών
(US) BeneFiber - What Are Probiotics and What Are Their Benefits?
(US) BeneFiber - What’s Your Gut means for your gealth
(UK) Optibac - Probiotics vs Digestive Enzymes
(Britannica) - large intestine has about ~1.5m length and diameter 4.8cm
(Britannica) - small intestine is about ~6m length and diameter 2.5cm
duodenum is the first and shortest segment of the small intestine (25-30cm), located inferior to the stomach and ends to the jejunum. (britannica)​
jejunum is the middle segment (2.5m) of the small intestine found between the duodenum and the ileum.​
ileum is the last part (3.5m) of the three part tube that makes up the small intestine. (britannica)​
(2024) Popular gut probiotic craps out in randomized controlled trial



products

Synbiotics, are preparations containing both prebiotic compounds and probiotic microbes. ref

Prefer capsule : The capsule must be swallowed whole, to allow the capsule to pass through the stomach and the active substance to reach the small intestine.

https://www.lepicol.com/lepicol-original-formula-180g-powder/p2 (skroutz) - prebiotic (psyllium + inulin) and probiotic (milk, soya) , Lactobacillus & Bifidobacterium strains. 20gr / day

Recommended dosage 1-2 times a day drink 5-6 capsules with liquid, preferably 30 minutes before meals. The average weight of 1 capsule is 0.6gr.
https://mogador.cz/portfolio/psyllium-probiotic-100-ks/ - prebiotic (psyllium) and probiotic, Bacillus strains, cant find the product on producer online site. 10gr / day

https://www.nowfoods.com/products/supplements/psyllium-husk-500-mg-veg-capsules (skroutz) - prebiotic (psyllium).

https://www.nestlehealthscience.com/brands/optifibre [2] - prebiotic (partially hydrolyzed guar gum) 25gr / day

https://jarrow.com/products/prebiotic-inulin-fos-6-3-oz-180-g-powder [2]- prebiotic patent beneo-Orafti Synergy1 combination of Inulin (chicory) and FOS (FructoOligoSaccharides)



2010 - The Brain in Your Gut (skip to 7m)
 

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csmKtb7.jpg

Endothelial cells cover the inner surface of the blood vessel, while the epithelial cells cover the inner surface of the internal organs and the outer surface of the human body. src

3nzi7l3.jpg

If you take a close look at epithelial cells using a microscope, you will see them tightly packed together. This helps make a protective barrier for our bodies. There are also some special door-like connections between each epithelial cell called gap junctions. The gap junctions are where the cells exchange nutrients. Unfortunately, sometimes viruses can use these doors to spread between cells, too!

Epithelial cells come in different shapes depending on where in the body they are found. These shapes are called squamous, cuboidal, columnar, and ciliated columnar. src


--



ZepRIoc.jpg

Epithelial cells form a layer that functions as a physical barrier facilitated by tight connections between each cell. The mucosal layer is a chemical barrier that is critical to limit the contact between the microbiome and epithelial cells. Immune cells (T-Cells) are also a major participant in the immune response and the tolerance of the host against external substances. source

Bacteria occupy the space, overlay the epithelial cells, and stick to the mucosa. Penetration of bacteria through the mucosal surface is an abnormal event; pathogens such as Shigella, Salmonella, and Campylobacter invade in this way. source


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source



Epithelial cells and 'Leaky Gut'
WF9cLek.jpg
source

During homeostasis, the intestinal epithelium is a highly dynamic structure and is estimated to completely self-renew every 4–7 days. source

homeostasis is the state of steady internal, physical, and chemical conditions maintained by living systems. This is the condition of optimal functioning for the organism and includes many variables, such as body temperature and fluid balance, being kept within certain pre-set limits.



The Gut Microbiome: How the Host and Microbial Communities Influence Each Other
https://www.swarthmore.edu/alumni-r...nd-microbial-communities-influence-each-other
video
 

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The seven core genera of microbial organisms most often used in probiotic products are
  • Lactobacillus
  • Bifidobacterium
  • Saccharomyces
  • Streptococcus
  • Enterococcus
  • Escherichia
  • Bacillus
source


Difference Between Lactobacillus and Bacillus Clausii

Lactobacillus
is a genus of probiotic bacteria and their live or dormant cells are mainly utilized as probiotics. On the other hand, Bacillus clausii is a probiotic bacterium, and its spores are mainly utilized as probiotics. So, this is the key difference between Lactobacillus and Bacillus clausii. Moreover, Lactobacillus species normally live in the human digestive system while Bacillus clausii normally live in the soil. source

MC3iPnV.jpg
 

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03/08/2022 - First day taking supplement /probiotic (Bacillus strains) + prebiotic/ - only with the (first) noon dose, I see healing to a skin problem have, already for 2 years now.. These years went to Allergists / Endocrinologists all found good but no solution given. Also is visible, the better meal digestion.



When the gut microbiome comes into balance with increased levels of beneficial bacteria and reduced levels of pathogenic bacteria, the individual may notice an improvement in their digestion and wellbeing. This is because gut pathogens produce many toxins and other substances that negatively affect our health, whereas probiotic strains of bacteria produce beneficial substances, including certain vitamins and short-chain-fatty-acids that have a positive impact on our overall health. source



Cell published :

06/09/2018 - BBC - Probiotics labelled 'quite useless'
  • You're more microbe than human - if you count all the cells in your body, only 43% are human
  • The rest is our microbiome and includes bacteria, viruses, fungi and single-celled archaea
  • The human genome - the full set of genetic instructions for a human being - is made up of 20,000 instructions called genes
  • But add all the genes in our microbiome together and the figure comes out at between two million and 20 million microbial genes
  • It's known as the second genome and is linked to diseases including allergy, obesity, inflammatory bowel disease, Parkinson's, whether cancer drugs work and even depression and autism


Impact of Cigarette Smoking on the Gastrointestinal Tract Inflammation

The main component of cigarette, tobacco, is a natural product with a complex molecular composition. During smoking, this complex biomass is subjected to high temperatures and varying oxygen concentrations, producing an incomplete combustion that generates more than 7,000 toxic compounds. It has been shown that chronic inhalation of cigarette smoke alters cell proliferation, endothelial function, and immune response.

In addition to the respiratory and cardiovascular effects produced by cigarette smoke, several studies suggest that smoking is also harmful to the gastrointestinal tract, cigarette smoke contains between 100 trillion free radicals per puff.

It has been shown that cigarette smoking increases the incidence and relapse of peptic ulcer disease, and has been associated with IBD, CD, and the development of esophageal, stomach, liver, pancreatic, and colon cancer. source
 

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Prebiotic

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What is the typical recommended serving of whole psyllium husks ?
  • For adults and children over 12 years of age, it’s 1 tablespoon mixed into 236ml of a liquid of your choice (water, juice, milk, etc.) 1–3 times daily.
  • For children 6–12, the recommended psyllium husk dosage is 1 teaspoon 1–3 times daily.
What is the typical recommended serving of psyllium husk powder ?
  • For adults and children over 12 years of age, it’s 1 teaspoon mixed into a liquid of your choice 1–3 times daily.
  • For children 6–12, the recommended dosage of psyllium husk powder is a half teaspoon 1–3 times daily.
Once the recommended serving of whole psyllium husks or psyllium husk powder is mixed well into at least 236ml of liquid, it will thicken up into a gel-like consistency (this is normal) and it should be consumed immediately. If the mixture is too thick, simply add more liquid. Per serving, whole psyllium husks (one tablespoon) and psyllium husk powder (one teaspoon) are usually both around 15–30 calories with 3.5 to six grams of dietary fiber.

You can also purchase psyllium in capsule form. The amount of psyllium husk per capsule varies by company but typically contain around 500–625 milligrams per capsule. source



Psyllium Husks vs Powder

Psyllium Husk - Caution don't take too much!



2021 - Researchers identify gut bacterium (Bifidobacterium) that inhibits SARS-CoV-2
2022 - Two important microbiota commensals, Bifidobacteria and Lactobacillus, are significantly reduced in COVID-19 patients



(Harvard) Foods that fight inflammation
5 Foods That Can Cause Inflammation
(US) Eating to Reduce Inflammation (mirror)
 

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Digestive System & How it Works

(UK) NIH - https://www.niddk.nih.gov/health-information/digestive-diseases/digestive-system-how-it-works
https://my.clevelandclinic.org/health/body/7041-digestive-system

Έντερο Explained

Digestion. Your stomach uses rhythmic churning and grinding motions (mechanical digestion) as well as stomach acid and enzymes (chemical digestion) to break down your meal.

After leaving your stomach, food then moves through your intestines:

Small intestine. In your small intestine, food mixes with additional digestive fluids. This is where most of the nutrient absorption takes place. Food can spend between 2 to 6 hours in your small intestine.

Large intestine. In your large intestine (colon), water is absorbed, and what’s left over from digestion is turned into stool. The waste products from your food spend around 36 hours in your large intestine.

In total, it can take between 2 to 5 days for food to move through your entire GI tract. source

Alcohol molecules are very small, so, when they hit your small intestine, they can easily pass through your gut wall and into your bloodstream.

Once alcohol is swallowed, it is not digested like food. First, a small amount is absorbed directly by the tongue and mucosal lining of the mouth. Once in the stomach, alcohol is absorbed directly into your blood stream through the tissue lining of the stomach and small intestine.

Alcohol is not digested like other foods. Once alcohol is swallowed, it travels down the esophagus into the stomach and the small intestine. It avoids the normal digestive process and goes right into the bloodstream.



The intestinal tract and the liver are anatomically and physiologically connected. This relationship between the two has been called the “gut–liver axis,” and the effects of intestinal metabolites on the liver are considered very important for the onset and progression of liver diseases. source



Phages control bacterial populations in nature, and clinicians are increasingly using them to treat bacterial infections that do not respond to antibiotics. reference
 

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The link between eczema, gut health, and the microbiome

Specifically, people with atopic dermatitis can have higher levels of

They may also have lower levels of helpful species of bacteria, such as:
  • Bacteroidetes
  • Akkermansia
  • Bifidobacterium
source



Staphylococcus bacteria Infections: What You Should Know

Staphylococcus Diagnosis



Keratinocytes at the lowest layer of the epidermis secrete immune-attracting and immune anti-inflammatory molecules. This is to attract immune cells to the skin and park them in place to wait patiently to fight off any pathogenic microbe or parasite that might break through the physical barrier of the skin. source
 

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(CZ) Tailor-made probiotics (06/2021)

The hidden micro world that we carry with us 24 hours a day affects more than we can possibly imagine. At the same time, only in recent years have scientists gradually revealed the importance of bacteria and microorganisms living in the human body, which, as it turns out, is not so completely human. There are more microscopic inhabitants in the body than human cells.

Currently, the Brno laboratory analyzes up to two thousand types of bacteria, which scientific and clinical research has shown to have a significant effect on human health. "For a whole range of bacteria, we know that their content should be within a certain range. It's like getting a blood test. We all have different results, but they must be within certain limits. If they swerve, something is fundamentally wrong,"

Antibiotics destroy the microbiome within a few days. But its restoration takes at least six months.

The customer pays 34,500czk (1.4k euros) for an annual individualized probiotic treatment including sample analyses. A six-month course will cost 19,000czk (774 euros).

The microbiome is directly or indirectly linked to every human disease.

A separate group consists of patients with neurodegenerative diseases such as Parkinson's or Alzheimer's disease. These begin precisely with changes in the intestinal microbiome and the intestinal nervous system approximately 10 to 15 years before the onset of the disease.

It's not just diarrhea, constipation, high cholesterol or immunity. The gut microbiome is key in cleansing and detoxifying the body.

A healthy microbiome, for example, reduces the risk of fractures, as it affects the absorption of calcium. Many clients use probiotics as prevention and health support. The correct functioning of the intestines is a fundamental prerequisite for a healthy life and longevity.

article is only visible on premium users, please try google. (mirror)

company site - https://harmonelo.com or https://pro-biotika.harmonelo.shop/e-shop.php (prices revealed 22/09/2022)


In the case of specific diseases such as histamine intolerance, the number of strains may be reduced, with an emphasis on safety and benefit to the client. Inform us about any such illnesses in the questionnaire before sending the sample, as it is not possible to take into account later additions during production!
 

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(SK / 2021) Ladislav Kuzela - I had a patient who ate only two foods

The gut microbiome should be viewed as your own pet that will reward you if you take good care of it. That's why some call it 'my inner Tamagotchi'. Maybe treat it the way we treat our pets

30 years ago, there were not so many inflammatory diseases - Crohn's disease, celiac disease, various intolerances. No one even knew there was such a thing as histamine intolerance. However, this is related to overall lifestyle, not just diet. We live longer, but less well.

We have about 39 trillion microbes in the gut, under which there is a layer of mucus, behind which the intestinal cells are closely arranged, which protect the immune system so that it does not have to constantly fight with foreign substances.

When bad microbes take over, the mucus layer is the first to be consumed and the proteins that bind the intestinal cells together become inflammatory. The intestine is therefore exposed and the so-called leaky gut occurs, i.e. the syndrome of increased intestinal permeability. Subsequently, the immune system is activated and chronic inflammation occurs, later intolerance and finally autoimmune disease.

One of the most important factors that can permanently damage the microbiome is chronic stress. It turns out that patients who suffer from it have a completely altered microbiome, with bad microbes predominating. Overuse of antibiotics or various drugs also plays a negative role.

To this day there is no examination that would 100% confirm functional disease of the digestive tract. The diagnosis of functional disorders is really only about symptoms.

The pets microbiome is completely different, so it creates the aforementioned diversity for you. Some authors of scientific studies have gone so far as to buy a dog and have it lick them just for the sake of it, hoping that this is a way to expand their microbiome. It goes to extremes, but it still has its rationale, a scientific basis. It is a fact that a person who owns a pet has a richer microbiome. source (mirror)

Ladislav Kuzela site
 

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Ιδιοπαθείς φλεγμονώδεις νόσοι εντέρου (ΙΦΝΕ)

είναι δύο νοσήματα που προκάλουν δια βίου φλεγμονή του πεπτικού σωλήνα
  • Ελκώδη κολίτιδα (μόνο παχή έντερο)
  • Crohn (οποιοδήποτε σημείο του γαστρεντερικού σωλήνα)

Τα νοσήματα αυτά ανήκουν στις αυτοάνοσες παθήσεις του οργανισμού. Τα νοσήματα αυτά χαρακτηρίζονται επίσης και από εκδηλώσεις σε όργανα εκτός του πεπτικού όπως από το μυοσκελετικό, οφθαλμούς, ήπαρ, δέρμα στο σύνολο των οποίων είναι γνωστές ως εξωεντερικές εκδηλώσεις των ΙΦΝΕ. source

Γαστροσκόπηση ref1 ref2



Επεμβατική Ακτινολογία

Εγγυάται την ακριβέστερη απεικόνιση, την ασφαλέστερη προσέγγιση και την πλήρη θεραπευτική αντιμετώπιση.

Πεπτικό Σύστημα: Διασφαγιτιδικές βιοψίες ήπατος, καθετηριασμός ηπατικών όγκων, εμβολισμός ηπατικών όγκων, διαδερμική έγχυση αιθανόλης σε ηπατικούς όγκους, χειρισμός κυστών – αιμαγγειωμάτων ήπατος κ.λπ. Ενδοπροθέσεις οισοφάγου, διαστολές οισοφάγου, διαστολές εντέρου και τοποθέτηση ενδοπροθέσεων, γαστρονομίες, νηστιδοστομίες. source



Why food intolerance tests fail to deliver on their promises

Around 40% of the planet’s inhabitants have some type of gastrointestinal problem. This was the conclusion of a recent analysis by an international team of scientists who collected data from 73,000 people in 33 countries on six continents. source

Food sensitivity is not a diagnosis, it is an invention and some opportunists are doing business with it.

Influence people into submitting to strict diets that can put their health at risk.

The only reliable method for diagnosing food intolerances is the detailed collection of information by the patient, including what foods are eaten and the symptoms that appear.

But the best approach, he concludes, is to exclude the food from the diet and see if the symptoms go away. source
 

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⭐ Role of Glutamine in Protection of Intestinal Epithelial Tight Junctions

In the small bowel mucosa, L-glutamine is an unique nutrient providing fuel for metabolism, regulating cell proliferation, repair and maintaining the gut barrier functions and the epithelial tight junction integrity.

Glutamine plays multiple roles in the maintenance of physiological homeostasis of diverse organs and cell types, glutamine is utilized at a high rate in rapidly dividing immune cells and promotes many functional activities of immune cells such as T-cell proliferation, B-cell differentiation, phagocytosis, antigen presentation, cytokine production and neutrophil superoxide production. The synthesis of glutathione, a major endogenous antioxidant in mammalian cells, requires glutamine as a precursor. Glutathione protects most cells from oxidative injury. During the normal life time 60 tons of food pass through gastrointestinal tract posing continuous threat to the integrity of gastrointestinal tract and whole body. Hence this organ is often under the challenge of inflammatory diseases and cancer. Gut mucosa is the major site of Glutamine metabolism. Due to its multiple roles in the gastrointestinal tract glutamine demand in the gastrointestinal mucosa is more than 15g/day, which is obtained mainly from systemic circulation as there is very little glutamine synthase activity in the gastrointestinal mucosa. Hence gastrointestinal mucosa derives glutamine formed in other tissue and also from diet for its metabolism. Glutamine is considered the most important nutrient for healing of ‘leaky gut syndrome’ because it is the preferred fuel for enterocytes and colonocytes. Gut barrier dysfunction and endotoxemia are associated with the pathogenesis of inflammatory bowel diseases, such as ulcerative colitis and Crohn’s disease. The tight junction is organized by four types of transmembrane proteins, occludin, claudins, tricellulin and junctional adhesion molecules, which interact with the scaffold proteins.

Gastrointestinal mucosal epithelium provides a structural and immunological barrier against the broad spectrum of noxious and immunogenic substances present the lumen of the gut. Compromised intestinal mucosal integrity and breakdown of gastrointestinal mucosal barrier function, a condition generically referred to as “Leaky Gut Syndrome”, are associated with starvation, injury, infection, immunosuppression, chemotherapy, and lack of enteral feedings, radiation and other types of stress. Disruption of gut mucosal integrity and barrier dysfunction results in increased permeability to allergens, toxins and pathogens, leading to immunological stress response and inflammation.

Stress, food allergies, alcohol, antibiotics, malnutrition are some of the factors that lead to leaky gut syndrome. Leaky gut or increased intestinal epithelial permeability has been implicated in the pathogenesis of several gastrointestinal diseases such as food allergies, IBD and IBS (65, 66). Glutamine is likely a potential intervention strategy for these diseases, as it reduces intestinal permeability from various stressors and helps maintain the normal intestinal barrier function. Glutamine in combination with N-acetyl cysteine and zinc partially restores the tight junction integrity and attenuated gut-derived inflammation.

source

Amy Myers MD - Leaky Gut Revive

Dose : L-Glutamine 3g / day

US / amazon reviews

EU Distro (verified) - REQUIRES INVITATION CODE
Functional Nutrition Ltd ( Amrita Nutrition UK / NL - SupplementHub UK )

Amy Myers MD - Gut Recovery Recipes



ION - Gut Support

Homepage : US / UK - (active ingredient humic extract)
UK Distro (verified) - YourHealthBasket (created 2009) > detoxpeople (2009) > naturesfix (2019) where says "active ingredient, Terrahydrite"
UK Distro (not verified) - Amrita Nutrition

What does ION Gut Support do?
Strengthens tight junction integrity at the gut lining, which protects the immune and neurologic systems and regulates the delivery of water and nutrients to the body.

As demonstrated in our peer reviewed articles, toxins like glyphosate and gluten can degrade tight junctions in the epithelial layer of the gut lining. ION Gut has been shown to promote the strengthening of this gut barrier, which supplies the first line of defense against everyday exposures to environmental and foodborne toxins. This in turn helps with inflammatory response, enhancing mental clarity, promoting immune function, supporting digestion, and alleviating gluten sensitivity.

Think of ION as an extremely intelligent transporter that works at a cellular level. ION isn't adding anything, it's facilitating partnership.

The fulvate molecules in ION are bacterial metabolites that bind with minerals, amino acids, etc. to help transport them into cells where they are needed. Further, fulvate can remove what is not needed and even harmful in the cell and transport it out.

Fulvate can even partner with metal ions. By promoting metal bridges between molecules, it encourages electron transfer both within and across molecules which helps facilitate the communication aspect of ION, what we refer to as "redox signaling". Encouraging cellular communication is truly profound, ultimately promoting innate cellular health. After all, a cell that can reach out and "ask" for what it needs will have an easier time getting it than a cell in isolation.

ION can also do things like donate electrons to free radicals (acting as an antioxidant), downregulate zonulin (the protein that weakens tight junctions), and diversify your gut microbiome by supporting the structure of your gut lining (where your microbiome lives). source


-ION.Gut Support, is this humic acid?
-ION is a pure water humic extract, and it does not contain isolated humic and fulvic acid.

Humic extracts are complexes of minerals and carbon family molecules from ancient composted soil, naturally rich in a variety of humate substances, trace minerals, and amino acids. ION*'s humic extract is composed of carbon backbone redox molecules with a unique signaling capability. In the case of most humic and fulvic supplements, they’re primarily used as a nutritional source of microminerals. While ION* does have micromineral content (it is sourced from humic soil), its primary function is as a signal, not a nutrient. This signaling ability is what makes ION* products unique. ION* will not replace other micromineral supplements taken as a nutrient source. source Amazon reviews

Terrahydrite is a lignite which contains humic acid within turn contains fulvic acid.

Fulvic acid has tremendous biological ability. Without it, no plant or animal could absorb enough nutrients and minerals to support life. source



(US / UK) supplement eshop - NineLife or CZ (possible scam!)



Activated vegetable carbon

Is full of pores which makes it extremely adsorbent. As a result, when ingested, activated charcoal has many benefits such as:
  • Absorbing excess gas in the intestines to prevent bloating and discomfort.
  • Absorbing some poisonous materials from the intestine in emergency patients who may have consumed toxic substances.
  • Promote kidney function by reducing the workload of the kidneys and removing waste products from the body.
  • Potentially reducing cholesterol levels by binding to bile acids in our gut and preventing them from being absorbed, having a beneficial effect on our harmful cholesterol levels.
  • Treating Diarrhea
  • Useful in the removal of noxious substances from the gastrointestinal tract (detox) providing natural support for a healthy digestive system
  • Particularly useful for people suffering from flatulence, bloating, cramps, and other digestive discomforts.
  • Travels through the digestive system binding with and adsorbing cholesterol, toxins, and other wastes source 2

Adsorption not to be confused with absorption is the opposite.

  • Can be taken during a course of one to two weeks.
  • Ιt should be taken at least 2 hours before or after any medication.

(AT) ftrenka.BioCarbon - produced in Austria
(GR) HerbStore - produced in Greece
(CZ) Carbofit - produced in Spain
 

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Malnutrition can be treated by encouraging the right gut bacteria

Microbiomes are easily unbalanced. Following Caesarean births, for example, babies are not exposed to bacteria from their mothers in the way that they are during vaginal births. Such transfers help determine the early microbial population of a child’s gut—and a third of Bangladeshi children are born by Caesarean section, compared with around a quarter in rich Western countries. Rebalancing microbiomes once they have been unbalanced is hard.

These tests led them to three “microbiota-directed complementary food” diets, which they called MDCF-1, -2 and -3, that seemed to encourage the animals microbiomes to mature.

MDCF-2, made from bananas, chickpeas, peanuts and soya, came on top. Children eating MDCF-2 continued making gains relative to the others.

Fed MDCF-2 twice a day for three months grew plumper and faster than a comparable group fed RUSF.

WHO is now attempting to make the new five-country trial realistic (will complete at 2025), those running programmes within it are required to build from the ground up. source

there is some evidence that getting out in nature, getting dirty, do some gardening or something - can also positively influence your gut microbiome.

People who have histamine intolerance it is not just food, that they have a damaged gut. There is a breakdown in the barrier of the gut they have increase intestinal permeability (leaky gut), which makes them more vulnerable to histamine intolerance, because histamine is in the food. ?? Dr. Will Bulsiewicz - On The Microbiome ??
 

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Can Quercetin Help Heal a Leaky Gut?

Think about your body as a donut and the digestive tract is the donut hole – technically, not “in” the donut. It’s easy to see now that our gut lining is exposed to everything we swallow – food particles, bacteria, dust, etc – and has to decide what to do with all that material! Think of the gut barrier as the decision-maker: some particles are allowed to pass through, while others are told to move on through.

When functioning normally, the gut barrier keeps us healthy by keeping out potentially hazardous materials and letting nutrients and water in. But when it starts to become more permeable (or “leaky”) than normal, we run into problems.

Researchers have discovered that mast cells play a part in developing leaky gut. While it’s been known for a long time that severe physical stress (i.e. trauma or surgery) causes intestinal permeability (leaky gut), newer research has shown that chronic stress also has this effect. Interestingly, researchers determined that it is the mast cells in the intestine that are responsible for the increase intestinal permeability (leaky gut) in these stressful situations.

When mast cells “degranulate” or become “unstabilized”, they release histamine, the chemical that causes allergy symptoms. But you have mast cells in your gut, too and when they “degranulate” or become “unstabilized” there, they cause leaky gut.

Quercetin aim for 800 mg twice a day or 400 mg three times a day for a total of 1,200 – 1600 mg per day. It’s very difficult to get these levels from food, so a supplement is a good choice. source [ref] (mirror)

Quercetin vs Quercetin Dihydrate

webmd :
Quercetin has been safely used in doses up to 1000mg daily for 12 weeks, might make kidney problems worse. Don't use quercetin if you have kidney problems. source (and read the reviews also!)

What Happens In A Digestive Enzyme Deficiency
Is Aloe Vera Actually Good For Leaky Gut? [2] [3]
 

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Unroasted coffee (aka green coffee) may contribute to leaky gut more than dark roasted coffee. Green coffee has a higher concentration of alpha-dicarbonyls, which are highly prone to glycation (the binding of sugars to proteins or lipids). However, both green and dark roasted coffee have advanced glycation end products (AGEs), which can induce inflammation and may exacerbate leaky gut. source
 

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What is SIBO ?
Small intestine bacterial overgrowth (SIBO) is a condition in which there are too many bacteria in the small intestine. It can be caused by a variety of factors, including:

  • Abnormalities in the structure of the small intestine that make it easier for bacteria to grow there.
  • Decreased movement of the small intestine (called "peristalsis"), which can occur as a result of certain medications, surgery, or conditions such as diabetes or hypothyroidism.
  • A weakened immune system, which can be caused by conditions such as HIV or AIDS, or by treatments such as chemotherapy.
  • The use of proton pump inhibitors (PPIs) or other medications that reduce the amount of acid in the stomach.
  • A diet that is high in carbohydrates and sugars, which can promote the growth of bacteria in the small intestine.
  • SIBO can also be caused by other underlying conditions, such as Crohn's disease, celiac disease, and irritable bowel syndrome (IBS). In some cases, the cause of SIBO may not be clear.

How SIBO diagnosed ?
There are several methods that can be used to diagnose SIBO:
  • Lactulose hydrogen breath test: This is the most common test used to diagnose SIBO. It involves drinking a solution containing lactulose, a type of sugar, and then measuring the amount of hydrogen and methane in the breath over the next two hours. An increase in the levels of hydrogen and/or methane can indicate the presence of SIBO.
  • Glucose breath test: This test is similar to the lactulose hydrogen breath test, but it involves drinking a solution of glucose instead of lactulose.
  • Small intestine aspiration: This test involves inserting a small tube through the nose and into the small intestine, and then collecting a sample of the fluid that is present there. The sample is then examined to determine the types and numbers of bacteria present.
  • X-ray or CT scan: These imaging tests can be used to examine the structure of the small intestine and look for abnormalities that might be causing SIBO.
  • Endoscopy: During this procedure, a small camera is inserted through the mouth and into the small intestine, allowing the doctor to directly visualize the inside of the intestine and look for signs of SIBO.

A combination of these tests may be used to diagnose SIBO.



Functional Medicine practitioner

A doctor in functional medicine works holistically. Believe what your looking for is referred to as a "Functional Doctor", they are a specialized kind of doctor that deals with all sorts of things, they take a different approach.
https://www.webmd.com/a-to-z-guides/what-is-a-functional-medicine-doctor

So far I can't find one that my insurance pays for (imagine that) but one is cheapish enough for me to see ($300-$400 visit). I found this site that will list any around your area, hope it helps!
https://www.ifm.org/find-a-practitioner/

source

Greece
https://nutritherapy.gr/
(IFM Certified) https://valiamakropoulou.gr/
 

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Colostrum provides the body with a unique complex of immune, growth factors, vitamins, minerals, enzymes, amino acids and other valuable components. Other mammals apart from humans born without immunity, therefore, even cow colostrum contains much more important components. It is up to 40 times more valuable substances in comparison with human. source

Several clinical studies demonstrate that bovine colostrum supplements help reduce leaky gut and it contains digestive enzymes that support healthy digestion. By helping to heal a leaky gut, colostrum is reported by many reviewers to help with their autoimmune conditions like arthritis and colitis. Is a supplement that is often very helpful for allergy symptoms and histamine intolerance.

More than 20% of the population in industrialized countries suffer from food intolerance or food allergy. study

Study showed that colostrum has additive benefits in reducing leaky gut for athletes. 8 people who were heavy exercisers received zinc carnosine alone or zinc carnosine plus colostrum. Those taking both the zinc and colostrum had greater improvements in gut permeability than those getting zinc only. study

Helps improve skin health for conditions like wound healing and eczema also helps speed up wound healing by increasing the growth of skin cells called keratinocytes. study

Fact: prior to the advent of antibiotics, colostrum was used to help reduce infections, but this use was lost after the popularity of antibiotics.

People who have a true milk allergy should avoid colostrum.

Omega-3 fats can be a good histamine supplement. This is because they work to dampen down inflammation and help support the body DAO production.

Many experts believe that the condition of histamine intolerance is related to a leaky gut. So focusing on healing the gut, including a gluten-free diet, may help improve histamine tolerance. More about gut-healing diet.

Hormones like estrogen also play a role in histamine intolerance. Women are more likely to have histamine intolerance than men. Research shows that estrogen production is closely linked to DAO production.

The more estradiol you have, the more histamine your body likely has. This is because estradiol breaks down DAO and another enzyme called monoamine oxidase, both of which break down histamine in the body.

Estrogen and DAO
Estrogen-dominant
person may suffer from reduced DAO and therefore, more histamine intolerance.

Progesterone also causes a breakdown of DAO but to a lesser degree than estrogen. This all likely explains why women have many varying symptoms from histamine. And the symptoms vary throughout their menstrual cycle and even as they hit menopause.

Fact: when boiling foods may decrease the histamine content of foods, while frying may increase the histamine content.

Is better to avoid all alcohol in general with histamine intolerance. This is because it alters estrogen levels, damages intestinal cells, and reduces body ability to detoxify. Alcohol also reduces your body absorption of nutrients.

source
Histamine Intolerance + All About Histamine
Comprehensive Leaky Gut Diet Guide + How To Heal Your Gut


----------------- ALL SUMMARIZED here -----------------
https://pipiscrew.github.io/timeline/#/health/gut
 

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Chicory root contains inulin prebiotic (crap)

Ρίζα κιχωρίου: Το τρόφιμο του μέλλοντος
είναι πλούσια σε πρεβιοτικά και οι φυτικές ίνες κιχωρίου μπορούν να προστεθούν σε προϊόντα όπως γιαούρτια, δημητριακά, ψωμιά, μπισκότα, επιδόρπια ή ποτά. «Η κατανάλωση τουλάχιστον 5 γραμμαρίων πρεβιοτικών ημερησίως συνιστάται για βελτιωμένη υγεία του εντέρου» source
Beneo (with HQ Germany)

2019 - source - video
Το μάθημα που πήραμε από τα κιχώρια αφορά στα τερπένια που βρίσκονται εδώ. Δεν είναι ευρέως γνωστό, αλλά πολλές από αυτές τις οργανικές ενώσεις έχουν φαρμακευτικές ιδιότητες. Προς το παρόν μόνο οι φυτικές ίνες εξάγονται. Αντιθέτως, τα τερπένια απομακρύνονται λόγω της πικρής τους γεύσης.

Η γκάμα των πιθανών χρήσεων των ενώσεων που παράγονται από τα ραδίκια είναι τεράστια: αντιβιοτικά, κρέμες προσώπου, τρόφιμα. Η διαδικασία βρίσκεται στον τελικό στάδιο, πριν βγει στο εμπόριο. reference -
Chic



Sodium butyrate ( sodium conjugate base of butyric acid )
Butyrate, is produced when good bacteria in your gut help your body break down dietary fiber in your large intestine (colon). Plays an important role in digestive system health by providing the main energy source for your colon cells, it meets about 70% of their energy needs. And it may provide other health benefits, too, including supporting your immune system, reducing inflammation and preventing diseases. source | video | doi



(IT) Euro-Pharma.ColonLife (Bionat importer in Greece)
  • Butyric acid ( Βουτυρικού οξέος )
  • GSE ( grapefruit seed extract )
  • probiotics ( Bifidobacterium breve br03 / Lactobacillus plantarum LP01 / Lactobacillus reuteri LRE02 )
  • prebiotic ( Fructooligosaccharides )
(IT) HQ - Euro-Pharma
It is recommended that tablets and capsules be taken separately, away from meals (aka 2 hours after meal).​



11/03/2024 - Ανησυχητικά τα ποσοστά αύξησης του καρκίνου του παχέος εντέρου παγκοσμίως


Συνέπειες της δυσβίωσης

Στο λεπτό έντερο η δυσβίωση οδηγεί σε ζύμωση των υδατανθράκων (μετατροπή των υδατανθράκων σε αέρια, σάκχαρα και αλκοόλες), ενώ στο παχύ έντερο οδηγεί σε σήψη των λιπαρών και πρωτεϊνικών ενώσεων επίσης σε αέρια σάκχαρα και αλκοόλες. Αμφότερες οι μορφές δυσβίωσης οδηγούν σε διαταραχές στον μεταβολισμό.

Στο ανώτερο πεπτικό η υπερβολική ανάπτυξη εχθρικών μικροβίων αλληλεπιδρά με την πέψη των υδατανθράκων, τουλάχιστον εν μέρη από την καταστροφή των πεπτικών ενζύμων από τις πρωτεάσες των βακτηριδίων. Αυτό έχει ως αποτέλεσμα την είσοδο στο παχύ έντερο υδατανθράκων που καταναλώνονται από τα μικρόβια που βρίσκονται εκεί, τα οποία αναπτύσσονται υπερβολικά με τις εξής συνέπειες :
  • πρήξιμο στην κοιλιά
  • αέρια
  • πόνο στην κοιλιακή χώρα κολικού τύπου
  • σύνδρομο διαπερατού εντέρου
Το σύνολο αυτών των συμπτωμάτων πολλές φορές αναφέρετε με το όρο σύνδρομο ευερέθιστου εντέρου ή σπαστική κολίτιδα. source

Οι φυτικές ίνες έχουν την ιδιότητα να δεσμεύουν τις τοξίνες στο έντερο και να τις αποβάλλουν μέσω των κοπράνων, πριν γίνει η εκ νέου απορρόφηση από τον ειλεό (ileum). source

Research stream in biological and neural science is how the gut microbiome the microorganisms residing in the gastrointestinal tract impacts behavior, cognition, and brain function in its host. source



asparagus

2023 - Assessment of their effect on the growth of human gut-associated bacteria
2016 - Researchers identified a flavonoid called rutin as contributing to reduce colon inflammation



DEC 2023 - First-in-human implantation of bionic device to halt Crohn disease
2015 - Totaly laparoscopic intersphincteric resection with turnbull–cutait delayed coloanal anastomosis (first video - at 20 minute)
2021 - ΥΓΕΙΑ - Ενδοσκοπική Κάψουλα - Η μοναδική μη επεμβατική μέθοδος απεικόνισης και διερεύνησης του λεπτού εντέρου
 

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Cooking with a pressure cooker

can have several benefits for your gut health and overall nutrition.
  • Faster Cooking Times: Pressure cookers cook food more quickly than traditional methods, which can help preserve nutrients that might otherwise be lost during longer cooking times.
  • Enhanced Digestibility: Pressure cooking can break down tough fibers in foods, making them easier to digest. This is particularly beneficial for legumes, grains, and certain vegetables, which can be hard on the digestive system if not cooked properly.
  • Retention of Nutrients: While some nutrients can be lost during cooking, pressure cooking often retains more vitamins and minerals compared to boiling or frying. The sealed environment of a pressure cooker minimizes nutrient loss.
  • Increased Fiber Intake: If you're cooking more legumes, whole grains, and vegetables in your pressure cooker, you may be increasing your fiber intake, which is beneficial for gut health.
  • Reduced Anti-Nutrients: Some foods contain anti-nutrients (like phytic acid in grains and legumes) that can inhibit nutrient absorption. Pressure cooking can help reduce these compounds, making nutrients more bioavailable.
In summary, pressure cooking can be a healthy cooking method that retains nutrients and improves the digestibility of foods, potentially leading to better gut health. However, the nutritional value of the food also depends on the ingredients you use and how you prepare them.

by chatGPT



Izzy
Fagor

If you want to cook from frozen, lots of people do. A good rule is to add 5 minutes of cook time per 2.5 cm of thickness.

If your recipe calls for diced meat, but you forgot to defrost it the night before, use your pressure cooker to defrost and partially cook smaller cuts of frozen meats, such as chicken breasts. Simply pour 1 cup (235 ml) water into your pressure cooking pot, place a trivet in the bottom, and arrange the frozen chicken breasts on the trivet. Lock the lid in place. Select High Pressure and 1 minute cook time. When the cook time ends, turn off the pressure cooker. Use a quick pressure release. Remove the chicken from the pot and dice it into small pieces and continue with the recipe as directed.

recipes - https://www.pressurecookingtoday.com/
Όσα χρειάζεται να γνωρίζετε για τη χύτρα ταχύτητας



The colourful fiveExample foods
PurpleBlueberries, aubergine, red grapes, purple plums, blackberries, red cabbage
RedTomatoes, strawberries, raspberries, cherries, red peppers
Orange/YellowCarrots, sweet potato, citrus fruits, mangoes, butternut squash
GreenBroccoli, kale, spinach, peas, green beans, courgette, herbs
White/pale yellowPotatoes, cauliflower, garlic, lychees, bananas

Top 15 polyphenol-rich herbs and spicesTotal polyphenol mg/100g
Cloves
16,048​
Cinnamon
9,7​
Dried marjoram
9,306​
Dried spearmint
6,575​
Dried basil
4,318​
Dried oregano
3,117​
Dried sage
2,92​
Caraway seeds
2,913​
Dried rosemary
2,519​
Dried camomile
2,483​
Dried coriander
2,26​
Dried fenugreek
2,25​
Turmeric powder
2,117​
Cumin seeds
2,038​
Nutmeg
1,905​

source
ps : better see an extensive list from another book author here.
 

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Obelisks - New Class of Life Has Been Found in Human Digestive System

https://www.sciencealert.com/obelis...-has-been-found-in-the-human-digestive-system
https://doi.org/10.1101/2024.01.20.576352



Αντιόξινα

Μερικά κοινά φαρμακευτικά προϊόντα είναι, τα μασώμενα δισκία Tums, τα μασώμενα δισκία Gaviscon και τα μασώμενα δισκία Maalox. [wiki]
Haleon.Tums - Τριβασικό φωσφορικό ασβέστιο
Reckitt.Gaviscon Double Action - Αλγινικό Νάτριο / Ανθρακικό ασβέστιο / Διττανθρακικό νάτριο [farmakonet] [wikihealth]
Sanofi.Maalox - Υδροξείδιο Αλουμινίου / Υδροξείδιο Μαγνησίου [farmakonet]
Γάλα μαγνησίας - Υδροξείδιο του μαγνησίου [webmd] [galinos]
P&G.Pepto-Bismol - Υποσαλικυλικό βισμούθιο

Το TUMS, το Pepto-Bismol ή το γάλα μαγνησίας, ειτουργούν εξουδετερώνοντας το οξύ του στομάχου. Όσοι υποφέρουν συχνά από γαστρίτιδα προσπαθούν να βρουν ανακούφιση με αυτά τα σκευάσματα. Ορισμένες μάρκες χρησιμοποιούν ακόμη και συνδυασμό τριών βασικών αλάτων: αλουμίνιο, ασβέστιο και μαγνήσιο, μαζί με διττανθρακικά ιόντα ή υδροξείδιο για την εξουδετέρωση του οξέος του στομάχου.

Υπάρχουν διάφορες ανεπιθύμητες παρενέργειες που είναι πιθανές όταν λαμβάνουμε αντιόξινα και σε αυτές συμπεριλαμβάνονται :
  • Τα αντιόξινα ενδέχεται να προκαλέσουν σύνδρομο γάλακτος-αλκάλεως ή σύνδρομο ασβεστίου-αλκάλεως και εξαρτώμενη από τη δόση αναγωγή υπερέκκρισης οξέος.
  • Τα αντιόξινα που περιέχουν υδροξείδιο του αργιλίου μπορούν να προκαλέσουν δυσκοιλιότητα, οστεομαλάκυνση, δηλητηρίαση από αλουμίνιο και υποφωσφαταιμία.
  • Τα αντιόξινα που περιέχουν ανθρακικό ασβέστιο μπορεί επίσης να προκαλέσουν δυσκοιλιότητα.
  • Τα αντιόξινα που περιέχουν μαγνήσιο θα μπορούσαν να προκαλέσουν μια καθαρτική επίδραση, οδηγώντας σε διάρροια. [1]



Βιολογικοί παράγοντες
Πρόκειται για ενέσιμα φάρμακα που λειτουργούν στοχεύοντας συγκεκριμένες πρωτεΐνες του ανοσοποιητικού που αποδεδειγμένα σχετίζονται με την εκδήλωση ψωρίασης, περιορίζοντας σε μεγάλο ποσοστό τις δερματικές βλάβες και οδηγώντας συχνά στην πλήρη υποχώρηση των συμπτωμάτων. [1]
 
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