Swiss Interest Group Histamine Intolerance
Histamine is a product of fermentation, maturation and putrefaction, which may be found in most foods in varying concentrations.
Histamine intolerance (HIT) is not an allergy but a metabolic disorder (impaired degradation of histamine) without involvement of the immune system.
Histamine is a substance, which is naturally produced in the body and regulates various functions (mediator, messenger, transmitter). In case of infections and allergic reactions, histamine puts the body's defense mechanisms on the alert. Histamine is also an inflammation mediator, a tissue hormone and neurotransmitter; it plays a role in the circadian rhythm, the bowel movements and many other processes. The body may produce histamine, store it in certain cell types and if necessary release it all at once. source
Please read the Dietary change (or) page and read the PDFs for Simplified elimination diet and Strict elimination diet.
DAO deficiency - histamine route within the organism
In the metabolism of histamine, when it should be degraded by DAO enzyme in order to become N-acetyl aldehyde imidazole, an accumulation of the amine is produced due to the lack of (DAO) enzyme in the intestinal mucosa cells. Low (DAO) enzyme activity causes the concentration of histamine, which comes from the food and is generally considered normal, not to be metabolized and a transepithelial permeation of exogenous histamine occurs.
This way, histamine enters the bloodstream increasing its plasma concentration and once located in blood it spreads throughout the body.
The most frequent symptoms derived from DAO Deficiency :
source
DAO supplements do not get into your bloodstream and cannot increase your DAO levels internally. This means that supplementing with the DAO enzyme only helps you break histamine down that you’re consuming. source
As per supplement DAOSin manual
What is histamine?
Histamine is a messenger substance belonging to the group of the so-called biogenic amines. It is formed by the body itself; however, it is also absorbed in a natural way as it is contained in many food products. Being a biologic messenger substance, histamine has various functions in the body. As a neurotransmitter, it gets involved – among other things – in the :
What happens to histamine taken up from food?
Normally, eating histamine-containing food will have no consequences since such food derived histamines will primarily and rapidly be broken down in the intestine already by the body own diamine oxidase (DAO) enzyme. When eating a high histamine diet, the activity of this diamine oxidase (DAO) enzyme may no longer be sufficient thus leading to delayed decomposition of histamine in the intestine. Moreover, alcohol and certain medications may significantly reduce the DAO enzyme activity. When the decomposition of histamine is delayed, its level in the body will increase for the moment.
Which foods contain histamine?
In particular, food aged (maturated) or stored for a long time will have a high content of histamine and other biogenic amines. In addition, a variety of foodstuffs is acting as so-called histamine liberators because they also do release histamine in the intestine. Some examples include the following foodstuffs:
How does DAOSiN work?
Taking one tablet of DAOSiN prior to a meal increases the DAO level in the intestine and thus the ability to break down histamine by natural DAO activity. One tablet of DAOSiN has an activity of 23 kHDU (histamine degrading units). Ingredient, protein extract from pig kidney.
webpage
ps: better get NATURDAO (derived by legumes) ----- DAOSin derived by pigs
Three basics :
Lower DAO activity has been discussed as a potential indicator of intestinal mucosa damage in inflammatory and neoplastic diseases and in persons undergoing chemotherapy.
Probiotics, specific some Lactobacillus strains can be beneficial, but they produce enough histamine that may cause trouble for those with histamine intolerance.
In addition to histamine-rich food, many foods such as citrus foods are considered to have the capacity to release histamine directly from tissue mast cells, even if they themselves contain only small amounts of histamine.
Mast cells are the immune cells that produce the most histamine in your body. They release stored histamine in response to a number of triggers, including allergens and infection.
Foods with histamine-releasing capacities :
Alcohol, especially red wine, is rich in histamine and is a potent inhibitor of DAO.
source
Adding as PDF the DrJockers - Are You Suffering From Histamine Intolerance as his website is full of ads..
He recently cracked histamine issue and explaining
You need to start eating things right out of the ground or right out of the freezer. Don't ever defrost something again by throwing it in lukewarm water. To defrost meats put them in an ice bath, and inside the fridge. Don't put things through multiple defrost/freeze cycles, so don't refreeze any meat or soup.
There are 4 types of problem foods for people with Histamine Intolerance
How Can Histamine Intolerance Affect You
Histamine and DAO can be count with blood test.
Ισταμίνη και διαμίνη οξειδάση (DAO) μπορούν να μετρηθούν με αιματολογική εξέταση.
Histamine is a product of fermentation, maturation and putrefaction, which may be found in most foods in varying concentrations.
Histamine intolerance (HIT) is not an allergy but a metabolic disorder (impaired degradation of histamine) without involvement of the immune system.
Histamine is a substance, which is naturally produced in the body and regulates various functions (mediator, messenger, transmitter). In case of infections and allergic reactions, histamine puts the body's defense mechanisms on the alert. Histamine is also an inflammation mediator, a tissue hormone and neurotransmitter; it plays a role in the circadian rhythm, the bowel movements and many other processes. The body may produce histamine, store it in certain cell types and if necessary release it all at once. source
Please read the Dietary change (or) page and read the PDFs for Simplified elimination diet and Strict elimination diet.
DAO deficiency - histamine route within the organism
In the metabolism of histamine, when it should be degraded by DAO enzyme in order to become N-acetyl aldehyde imidazole, an accumulation of the amine is produced due to the lack of (DAO) enzyme in the intestinal mucosa cells. Low (DAO) enzyme activity causes the concentration of histamine, which comes from the food and is generally considered normal, not to be metabolized and a transepithelial permeation of exogenous histamine occurs.
This way, histamine enters the bloodstream increasing its plasma concentration and once located in blood it spreads throughout the body.
The most frequent symptoms derived from DAO Deficiency :
- Migraine and other vascular headaches.
- Gastrointestinal disorders, especially those associated with irritable bowel syndrome, such as constipation, diarrhea, satiety, flatulence or swollen feeling.
- Dermatological disorders such as dry skin, atopy or psoriasis.
- Soft-tissue pains usually diagnosed as fibromyalgia.
- Chronic fatigue.
source
DAO supplements do not get into your bloodstream and cannot increase your DAO levels internally. This means that supplementing with the DAO enzyme only helps you break histamine down that you’re consuming. source
As per supplement DAOSin manual
What is histamine?
Histamine is a messenger substance belonging to the group of the so-called biogenic amines. It is formed by the body itself; however, it is also absorbed in a natural way as it is contained in many food products. Being a biologic messenger substance, histamine has various functions in the body. As a neurotransmitter, it gets involved – among other things – in the :
- neurotransmission, immunomodulation, hematopoiesis, wound healing
- regulation of the sleep-wake rhythm
- regulation of the appetite control
- learning ability
- memory capacity
What happens to histamine taken up from food?
Normally, eating histamine-containing food will have no consequences since such food derived histamines will primarily and rapidly be broken down in the intestine already by the body own diamine oxidase (DAO) enzyme. When eating a high histamine diet, the activity of this diamine oxidase (DAO) enzyme may no longer be sufficient thus leading to delayed decomposition of histamine in the intestine. Moreover, alcohol and certain medications may significantly reduce the DAO enzyme activity. When the decomposition of histamine is delayed, its level in the body will increase for the moment.
Which foods contain histamine?
In particular, food aged (maturated) or stored for a long time will have a high content of histamine and other biogenic amines. In addition, a variety of foodstuffs is acting as so-called histamine liberators because they also do release histamine in the intestine. Some examples include the following foodstuffs:
- Alcohol, in particular red wine and sparkling wine
- Cheese
- Seafood, fish and fish sauces
- Raw sausages, such as salami or ham
- Sauerkraut
- Various vegetables, such as tomatoes, spinach, eggplant
- Various types of fruit, i.e. strawberries, pineapples, bananas
How does DAOSiN work?
Taking one tablet of DAOSiN prior to a meal increases the DAO level in the intestine and thus the ability to break down histamine by natural DAO activity. One tablet of DAOSiN has an activity of 23 kHDU (histamine degrading units). Ingredient, protein extract from pig kidney.
webpage
ps: better get NATURDAO (derived by legumes) ----- DAOSin derived by pigs
Three basics :
- stored histamine in the body, formed by the body itself; however, it is also absorbed in a natural way by foods
- histamine coming from foods and is broken down by DAO enzyme
- foods trigger an inflammatory response in an intolerant person ( have the capacity to release histamine directly from tissue mast cells )
Lower DAO activity has been discussed as a potential indicator of intestinal mucosa damage in inflammatory and neoplastic diseases and in persons undergoing chemotherapy.
| Food categories | Histamine | |
| mg/kg | mg/L | |
| Fish (frozen/smoked or salted/canned) | ||
| Mackerel | 1–20/1–1788/ND–210 | |
| Herring | 1–4/5–121/1–479 | |
| Sardine | ND/14–150/3–2000 | |
| Tuna | ND/ND/1–402 | |
| Cheese | ||
| Gouda | 10–900 | |
| Camembert | 0–1000 | |
| Cheddar | 0–2100 | |
| Emmental | 5–2500 | |
| Swiss | 4–2500 | |
| Parmesan | 10–581 | |
| Meat | ||
| Fermented sausage | ND–650 | |
| Salami | 1–654 | |
| Fermented ham | 38–271 | |
| Vegetables | ||
| Sauerkraut | 0–229 | |
| Spinach | 30–60 | |
| Eggplant | 26 | |
| Tomato ketchup | 22 | |
| Alcohol | ||
| White wine | ND–10 | |
| Red wine | ND–30 | |
| Top-fermented beer | ND–14 | |
| Bottom-fermented beer | ND–17 | |
| Champagne | 670 |
Probiotics, specific some Lactobacillus strains can be beneficial, but they produce enough histamine that may cause trouble for those with histamine intolerance.
- Lactobacillus casei
- Lactobacillus reuteri
- Lactobacillus delbrueckii ssp. bulgaricus
- Curcumin. In one study, curcumin inhibited the release of DAO in the intestines of rats; however, it also appeared to prevent mast cells from releasing histamine.
In addition to histamine-rich food, many foods such as citrus foods are considered to have the capacity to release histamine directly from tissue mast cells, even if they themselves contain only small amounts of histamine.
Mast cells are the immune cells that produce the most histamine in your body. They release stored histamine in response to a number of triggers, including allergens and infection.
Foods with histamine-releasing capacities :
| Plant-derived | Animal-derived | Other |
| Citrus fruit | Fish | Additives |
| Papaya | Crustaceans | Liquorice |
| Strawberries | Pork | Spices |
| Pineapple | Egg white | |
| Nuts | ||
| Peanuts | ||
| Tomatoes | ||
| Spinach | ||
| Chocolate |
Alcohol, especially red wine, is rich in histamine and is a potent inhibitor of DAO.
source
Adding as PDF the DrJockers - Are You Suffering From Histamine Intolerance as his website is full of ads..
He recently cracked histamine issue and explaining
You need to start eating things right out of the ground or right out of the freezer. Don't ever defrost something again by throwing it in lukewarm water. To defrost meats put them in an ice bath, and inside the fridge. Don't put things through multiple defrost/freeze cycles, so don't refreeze any meat or soup.
There are 4 types of problem foods for people with Histamine Intolerance
- Actual histamines: from spoilage
- Histamine Liberators: food like garlic, nuts, citrus, and chocolate have no histamine BUT do cause your body to produce histamines in order to digest them. These foods don't produce an immediate response, and the symptoms could happen over the course of the next 3 days.
- Other biogenic amines: Since histaDINe is usually only in animals with circulatory systems, plants that cause symptoms actually have a different amines, (putrescine, cadaverine, spermine) that build up. This stupid stuff hogs the enzyme that breaks down histamine, keeping it in your system longer. You'll find these in lots of flour and breads.
- DAO blockers also cause symptoms: Like biogenic amines these type of foods hog the enzymes that could be used to eliminate histamines, leading to a build-up of histamine in the blood. Alcohol, and spicy foods interact with the histamine system in this way, because DAO breaks down histamine. Fun fact: The feeling of an alcohol hangover is due to histamine saturation that occurs in the blood.
- Wine, and chili paste actually actually contain all 4 types^ of histamine irritants above, making them the worst foods you could eat, and guaranteeing symptoms.
- Keep potatoes to fridge
- Canned or dried foods not allowed
- Vinegar is the absolute worse. Even just a few drops in a marinade or sauce and it will cause you pain. This is the hardest part of the whole thing for me.
- Don't eat any fermented foods. Alcohol included.
How Can Histamine Intolerance Affect You
Histamine and DAO can be count with blood test.
Ισταμίνη και διαμίνη οξειδάση (DAO) μπορούν να μετρηθούν με αιματολογική εξέταση.
