International glycemic index database from the University of Sydney
Glycemic Load Calculator [
2] [
3]
Glycaemic index & Glycaemic load explained
Cholesterol drug
zentiva.Torvacard Neo [
2] (Czech manufacturer) is essentially similar to
viatris.Lipitor
active substance is
Atorvastatin
Core
- Calcium carbonate
- Cellulose, microcrystalline (E 460)
- Lactose monohydrate
- Low-substituted hydroxypropyl cellulose
- Povidone K12
- Silica, colloidal anhydrous
- Magnesium stearate (E 572)
Coating
- Hypromellose (E 464)
- Macrogol 6000
- Titanium dioxide (E 171)
- Talc
- Iron oxide yellow (E 172)
- Lactose monohydrate
The
E171 initially on 2017 found in
France that has carcinogenic effects. Substance banned in Germany.
The
E172 banned in Germany.
at 2017
(2019) Risk Management Plan for
Atorvastatin Zentiva &
Torvacard Neo
Rhabdomyolysis - breakdown of muscle tissue that releases a damaging protein into the blood.
Statins detail :
simvastatin / pravastatin - at night because they have a small duration of action.
atorvastatin / pitavastatin / rosuvastatin - any time, have long duration.
source
(2021) E171 -
EFSA said no longer considered safe [
2]
(2022)
Goodbye E171: The EU bans titanium dioxide as a food additive - Has just banned titanium dioxide/Ti02 (also known as E171) as a food additive
-Is titanium dioxide also being banned in non-food products?
-Will still be authorised for use in medicinal products until other safe alternatives are found. This is to avoid causing shortages of medicinal products that could negatively impact public health or animal health and welfare.
In
January 2022, a regulation was issued to withdraw the authorization for the use of titanium dioxide as a food additive in food, aka
EU Commission Regulation 2022/63.
This regulation
entered into force on February 7, 2022. However, the regulation included a
six-month transition period to give food businesses time to
phase out the use of this food additive and reformulate the recipes in their products using suitable alternatives. This period ended on August 7, 2022.
Foods before 7 August 2022 can
remain on the market
until the written, end date of consumption. Food produced or placed on the market after 7 August 2022 cannot contain titanium dioxide.
source
(2023) Atorvastatin -
Product Information
(1995) Atorvastatin -
Reduction of LDL Cholesterol by 25% to 60% in Patients
(2004) Μινέρβα
Benecol από αιγοπρόβειο γάλα (
0.1gr υδατάνθρακες + 6gr καρεσμένα λιπαρά) ( 25gr = 1.1gr στανόλες ) [
2]
Random products contain E171 :
Supplement
(2024)
Japan: Fifth suspicious death in dietary supplement scandal Monacolin K (Greek)
Monascus purpureus also known as
red yeast rice has been traditionally used in
China for hundreds of years as a spice added to foods. Only in the 20th century it was discovered that the Chinese did
not suffer from
high cholesterol due to the
consumption of this spice. Monascus purpureus contains a
natural substance called Monacolin K. In September 2011,
European Food Safety Authority (EFSA) approved a health claim for
Monacolin K extracted from
Monascus purpureus as a
natural cholesterol management dietary supplement in a concentration of
10 mg per dose. reference
(2011) EFSA Journal 2011;9(7):2304
Red yeast rice,
monacolin K (aka lovastatin), was the
first statin commercialised by pharmaceutical companies. Therefore, monacolin K may be considered a drug in several European countries. Despite the fact that red yeast rice is a
borderline ingredient between food
supplements and
drugs, the European Food Safety Authority has
recognised the cholesterol-
lowering properties of monacolin K in the evaluation of two health claims, and the European Commission has
validated a
health claim related to monacolin K and the
maintenance of normal blood LDL-cholesterol concentration in Regulation (EC) No.
432/2012.
source (2015)
Monacolin K is a naturally occurring compound found in red yeast rice, specifically from the
fermentation of
Monascus purpureus. It has been found to have a chemical
structure similar to the
prescription statin drug
lovastatin. Lovastatin and other statins are commonly prescribed to lower cholesterol levels. While monacolin K can be
effective in lowering cholesterol, it's important to note that it essentially functions as a natural statin and
may carry some of the same risks and side effects
as synthetic statin medications.
(CA)
Cholestatin -
Romanian distro (20e) | same domestic
Romanian language only (13e) --- 10mg of Monacolin K
(PL)
Cholesten
(GR) Drugs with
lovastatin
(IT)
Zeta Colest -
Φυσικά Συστατικά στη Ρύθμιση των Λιπιδίων (Red Yeast Rice + Berberis) ---
2.9mg of Monacolin K
In particular, its
effectiveness is directly related to the amount of
monacolin K within the extract (up to 10 mg/day). Consuming monacolin K on a daily basis
reduces low-density lipoprotein (LDL) cholesterol plasma levels between
15% and 25% within
6 to 8 weeks.
source
Monacolin K and
lovastatin are closely related compounds, and in fact, monacolin K is the
naturally occurring
form of
lovastatin. Both substances have
similar chemical structures and mechanisms of action. Here are the key differences and similarities between monacolin K and lovastatin:
Source:
Monacolin K: This compound is naturally found in red yeast rice (Monascus purpureus) as a result of the fermentation process.
Lovastatin: It is a synthetic statin drug that was originally derived from the fermentation of a different fungus, Aspergillus terreus. Lovastatin is then processed and manufactured as a prescription medication.
Chemical Structure:
Monacolin K: It is a naturally occurring compound that is structurally identical to lovastatin.
Lovastatin: This is the synthetic form of monacolin K. The chemical structures of the two compounds are essentially the same.
Medical Use:
Monacolin K: Found in red yeast rice and used as a dietary supplement for its potential cholesterol-lowering effects.
Lovastatin: Prescribed as a medication to lower cholesterol levels and reduce the risk of cardiovascular events.
Regulation:
Monacolin K: Often marketed as a dietary supplement, which is regulated differently from prescription medications.
Lovastatin: Available only as a prescription medication, subject to stricter regulatory oversight.
Dosage Control:
Monacolin K: The content of monacolin K in red yeast rice supplements can vary, and the potency may not be standardized.
Lovastatin: Pharmaceutical formulations allow for precise dosage control, ensuring consistency in the amount of the active ingredient.
Safety and Side Effects:
Both monacolin K and lovastatin may have similar side effects, including muscle pain, liver enzyme abnormalities, and gastrointestinal issues.
Lovastatin, being a regulated prescription medication, has undergone extensive clinical testing, and its safety profile is well-documented.
Overall
lovastatin got a pharma copyright and is ready to be sold as drug.
Iasis.Glipal [
2] (Greek manufacturer)
active substance is
Simvastatin
- Magnesium Stearate
- Talc
- Ascorbic Acid
- Lactose Monohydrate
- Ethanol
- Hyprolose
- Hypromellose
- Butylated Hydroxianisole
- Titanium Dioxide E171
- Citric Acid Monohydrate
- Cellulose Microcrystalline
- Water Purified
- Starch Pregelatinized
Statins can
affect the
production of
other substances in the body, including
CoQ10. CoQ10 is important for the functioning of
mitochondria, which are the
energy-producing units in
cells, and it is particularly
vital for the
heart, which has high energy demands. The degree of CoQ10 depletion with red yeast rice (aka
monacolin K) supplements may be
less than that observed with some
synthetic statins.
Statins primarily affect the production of cholesterol in the body. They work by
inhibiting an
enzyme called
HMG-CoA reductase, which is involved in the
synthesis of cholesterol in the
liver.
other substances affected apart CoQ10
- Dolichols: Statins may affect the production of dolichols, which are involved in the glycoprotein synthesis and modification processes.
- Isoprenoids: Statins can influence the levels of isoprenoids, potentially affecting the activity of certain proteins.
Glucose
AST (SGOT) - Enzymes are not really supposed to be in the blood, they end up in the blood when the cells wear out and they spill their content.
ALT (SGPT) - Mostly specifc to liver.
Total Cholesterol
Triglycerides - fat in the blood, indicator of insulin resistance.
VLDL Cholesterol Cal - deliver Triglycerides into to circulation, indicator of insulin resistance.
LDL-C (NIH Calc) - healthy LDL (statins lower only this, no 'Small LDL-P').
LDL-P
Small LDL-P - represents the degree of inflammation and oxidative stress.
